Diisobutylamine → {2-[5-diisobutylcarbamoyl-2-(3,5-dimethylphenyl)-1H-indol-3-yl]-ethyl}carbamic acid tert-butyl ester
반응식
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[C:17]([C:20]([OH:22])=O)[CH:18]=2)[NH:13][C:12]=1[C:23]1[CH:28]=[C:27]([CH3:29])[CH:26]=[C:25]([CH3:30])[CH:24]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].ON1C2C=CC=CC=2N=N1.Cl.CN(C)CCCN=C=NCC.[CH2:53]([NH:57][CH2:58][CH:59]([CH3:61])[CH3:60])[CH:54]([CH3:56])[CH3:55]>>[C:1]([O:5][C:6](=[O:7])[NH:8][CH2:9][CH2:10][C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[C:17]([C:20](=[O:22])[N:57]([CH2:58][CH:59]([CH3:61])[CH3:60])[CH2:53][CH:54]([CH3:56])[CH3:55])[CH:18]=2)[NH:13][C:12]=1[C:23]1[CH:28]=[C:27]([CH3:29])[CH:26]=[C:25]([CH3:30])[CH:24]=1)([CH3:2])([CH3:3])[CH3:4]참가 물질
5
반응물 4
생성물 1
실험 절차
To a solution of 3-(2-tert-butoxycarbonylaminoethyl)-2-(3,5-dimethylphenyl)-1H-indole-5-carboxylic acid (200 mg in 12 mL methylene chloride) was added 104 mg 1-hydroxybenzotriazole followed by 118 mg 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and the mixture stirred at room temperature. After 30 minutes, 0.35 mL of diisobutylamine was added and the mixture stirred at room temperature for 14 hours. The reaction was then concentrated in vacuo and purified by flash chromatography on silica gel (hexane:ethyl acetate, 2:1) to give the title compound (230 mg).
후처리
- stirringthe mixture stirred at room temperature for 14 hours
- concentrationThe reaction was then concentrated in vacuo
- custompurified by flash chromatography on silica gel (hexane:ethyl acetate, 2:1)
출처 및 근거
- ORD 기록
- ord-3fb7c9def1104f58913f156b686bf643
- 출처 데이터셋
- uspto-grants-2000_12
- 특허 번호
- US06156767
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