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Benzylamine → 2-Benzylamino-6-(t-butylamino)-3,5-difluoropyridine

HRID 1274657
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인쇄 미리보기

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HRID 1274657 반응식
CN1CCCC1=O.[C:8]([NH:12][C:13]1[C:18]([F:19])=[CH:17][C:16]([F:20])=[C:15](F)[N:14]=1)([CH3:11])([CH3:10])[CH3:9].[CH2:22]([NH2:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>C(Cl)(Cl)Cl>[CH2:22]([NH:29][C:15]1[C:16]([F:20])=[CH:17][C:18]([F:19])=[C:13]([NH:12][C:8]([CH3:11])([CH3:10])[CH3:9])[N:14]=1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 7504BenzylamineHCID 13387N-methyl-2-pyrrolidoneHCID 22121202N-(tert-butyl)-3,5,6-trifluoropyridin-2-amine

생성물 1

HCID 221212732-Benzylamino-6-(t-butylamino)-3,5-difluoropyridine수율 119.2%

시약·촉매·용매 1

HCID 6212Chloroform용매

반응 조건

온도
160 °C

실험 절차

To 20 ml of N-methylpyrrolidone were added 9.7 g of 2-(t-butylamino)-3,5,6-trifluoropyridine together with 15.5 g of benzylamine, and the mixture was stirred at 160° C. for one day and allowed to cool. After adding 50 ml of chloroform, the mixture was washed three times with 500 ml of distilled water. The chloroform layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain about 16.5 g of the title compound as a dark green oil.

후처리

  1. temperatureto cool
  2. washthe mixture was washed three times with 500 ml of distilled water
  3. dry with materialThe chloroform layer was dried over anhydrous magnesium sulfate
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-f92985c04a1b45548e0a3e2c12b7b735
출처 데이터셋
uspto-grants-2000_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06156903

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