4-Amino-1-butanol → HCID 178526250, 화합물

HRID 1274976

반응식

HRID 1274976 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][OH:6].Cl.Cl[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N+:10]=1[O-:15].C([O-])(O)=O.[Na+]>C(O)(CC)(C)C.CCO>[OH:6][CH2:5][CH2:4][CH2:3][CH2:2][NH:1][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N+:10]=1[O-:15]

참가 물질

6

반응물 3

HCID 258684-Amino-1-butanolHCID 88478Chloride 2-chloropyridinium 1-oxideHCID 516892Sodium Bicarbonate

생성물 1

HCID 178526250HCID 178526250, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매HCID 64052-Methyl-2-butanol용매

실험 절차

A mixture of 4-amino-1-butanol (1.76 g, 20 mmol), 2-chloropyridine N-oxide hydrochloride (3.98 g, 24 mmol), and NaHCO3 (8.40 g, 100 mmol) in tert-amyl alcohol (50 mL) is heated at reflux under argon. After 48 h, the reaction is cooled, diluted with EtOH, filtered, and concentrated. The residue is reconcentrated from toluene, and chromatographed (silica gel) to give the title compound.

후처리

  1. temperatureis heated
  2. temperatureat reflux under argon
  3. temperaturethe reaction is cooled
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customchromatographed (silica gel)

출처 및 근거

ORD 기록
ord-3b6c24c0bc6444779df62ea104da4529
출처 데이터셋
uspto-grants-2000_12
특허 번호
US06159964

연결된 노트

불러오는 중…