Hydrochloric Acid → 7-(3,4-Methlenedioxyphenyl)-2,3-dihydro-1-benzoxepine-4-carboxylic acid

HRID 1277279노트

반응식

HRID 1277279 반응식
[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([C:10]3[CH:11]=[CH:12][C:13]4[O:19][CH2:18][CH2:17][C:16]([C:20]([O-:22])=[O:21])=[CH:15][C:14]=4[CH:23]=3)=[CH:4][C:3]=2[O:2]1.[OH-].[Na+].Cl>CO>[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([C:10]3[CH:11]=[CH:12][C:13]4[O:19][CH2:18][CH2:17][C:16]([C:20]([OH:22])=[O:21])=[CH:15][C:14]=4[CH:23]=3)=[CH:4][C:3]=2[O:2]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 184722037-(3,4-Methylenedioxy-phenyl)-2,3-dihydro-1-benzoxepine-4-carboxylate

생성물 1

HCID 184722047-(3,4-Methlenedioxyphenyl)-2,3-dihydro-1-benzoxepine-4-carboxylic acid수율 84%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

In methanol (5 ml) was suspended 7-(3,4-methylenedioxy-phenyl)-2,3-dihydro-1-benzoxepine-4-carboxylate (399 mg, 1.23 mmol), and to the mixture was added 1N sodium hydroxide solution (3.69 ml). The mixture was stirred at room temperature for 20 hours, and to the mixture was added 1N hydrochloric acid (3.69 ml). The mixture was concentrated under reduced pressure, and to the residue was added water. Insoluble materials were filtered, which were washed with water and diethylether and dried under reduced pressure to give 7-(3,4-methylenedioxyphenyl)-2,3-dihydro-1-benzoxepine-4-carboxylic acid(321 mg, 1.03 mmol, 84%).

후처리

  1. concentrationThe mixture was concentrated under reduced pressure
  2. additionto the residue was added water
  3. filtrationInsoluble materials were filtered
  4. washwhich were washed with water and diethylether
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-bd92db416ab94f6d9f32f0446d150464
출처 데이터셋
uspto-grants-2000_12
특허 번호
US06166006

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