Hydrochloric Acid → HCID 45263932, 화합물

HRID 1277955노트

반응식

HRID 1277955 반응식
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]2[CH:12]=[C:13]([C:15]([O:17]CC)=[O:16])[N:14]=[C:4]2[CH:3]=1.[OH-].[Na+].Cl>C(O)C>[ClH:1].[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]2[CH:12]=[C:13]([C:15]([OH:17])=[O:16])[N:14]=[C:4]2[CH:3]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 12763962HCID 12763962, 화합물

생성물 1

HCID 45263932HCID 45263932, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

820 mg of ethyl 5-chloroimidazo-[1,2-a]-quinoline-2-carboxylate were dissolved in 50 ml of ethanol and 6.6 ml of 0.5 N sodium hydroxide solution were added to the solution obtained. The resultant mixture was refluxed for 1 hour, then was cooled to room temperature and acidified to a pH of ~1 by addition of concentrated hydrochloric acid. The solvent was removed under vacuum and the residue was dissolved in methanol. The solution formed was filtered and the filtrate was reduced in volume under vacuum and then was cooled to obtain off-white crystals of 5-chloroimidazo-[1,2-a]-quinoline-2-carboxylic acid hydrochloride melting at 263°-265° C. (decomposition).

후처리

  1. customobtained
  2. customThe solvent was removed under vacuum
  3. dissolutionthe residue was dissolved in methanol
  4. customThe solution formed
  5. filtrationwas filtered
  6. temperaturewas cooled

출처 및 근거

ORD 기록
ord-7ea61fb106854c19a8506925ad73ed4f
출처 데이터셋
uspto-grants-1981_07
특허 번호
US04279912

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