Hydrochloric Acid → 5,5-Bis(4-hydroxyphenyl)hydantoin

HRID 1278256노트

반응식

HRID 1278256 반응식
[OH:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)=O)=[CH:4][CH:3]=1.[C-]#[N:18].[K+].[C:20](=[O:23])([O-])[O-].[NH4+].[NH4+].[CH:26]([NH2:28])=[O:27].Cl>O>[OH:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]2([C:8]3[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=3)[NH:18][C:26](=[O:27])[NH:28][C:20]2=[O:23])=[CH:4][CH:3]=1

참가 물질

7

반응물 5

HCID 313Hydrochloric AcidHCID 713FormamideHCID 9032Potassium CyanideHCID 691504,4'-DihydroxybenzophenoneHCID 517111Ammonium Carbonate

생성물 1

HCID 1488755,5-Bis(4-hydroxyphenyl)hydantoin

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

100 Grams of 4,4'-dihydroxybenzophenone, 152.1 g of potassium cyanide and 426.3 g of ammonium carbonate were heated to 120° C. together with 750 ml. of formamide and 150 ml. of water with stirring in an autoclave for 48 hours. The reaction liquid was made acidic with concentrated hydrochloric acid, mixed with water and allowed to stand overnight. The precipitates thus formed were filtered out. The precipitates were decolorized by active carbon and recrystallized from 50% methanol to obtain 111.4 g of 5,5-bis(4-hydroxyphenyl)hydantoin in the form of white crystals.

후처리

  1. customThe reaction liquid
  2. customThe precipitates thus
  3. customformed
  4. filtrationwere filtered out
  5. customrecrystallized from 50% methanol

출처 및 근거

ORD 기록
ord-e76319feab26461eaadea0e8e0d9208d
출처 데이터셋
uspto-grants-1981_07
특허 번호
US04281009

반응 노트

불러오는 중…