Acetic Anhydride → 6-Acetamidopyridine-3-carboxamide

HRID 127943노트

반응식

HRID 127943 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][N:3]=1.[C:11](OC(=O)C)(=[O:13])[CH3:12]>CS(C)=O>[C:11]([NH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][N:3]=1)(=[O:13])[CH3:12]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 95006-Aminonicotinamide

생성물 1

HCID 2529266-Acetamidopyridine-3-carboxamide

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

6-Amino nicotinamide 13.7 g (0.1 mole) is dissolved in 100 ml of dimethylsulfoxide and acetic anhydride 14.2 ml (0.15 mole) is added to the above solution. The mixture is stirred at room temperature for 16 hours. White crystals which are formed during the reaction are isolated by filtration and are purified by washing with 0.2 N HCl and ethanol. 6-Acetylamino nicotinamide 9.5 g thus synthesized is practically pure as shown by infrared spectroscopy and thin-layer chromatography.

후처리

  1. customWhite crystals which are formed during the reaction
  2. customare isolated by filtration
  3. customare purified
  4. washby washing with 0.2 N HCl and ethanol
  5. custom6-Acetylamino nicotinamide 9.5 g thus synthesized

출처 및 근거

ORD 기록
ord-3882579bd32c45989f054d56f505c570
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04258052

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