Trimethyl borate → 2,5-Dimethoxyphenylboronic acid

HRID 1279959

반응식

HRID 1279959 반응식
F[C:2]1[CH:3]=[CH:4][C:5]([O:11][CH3:12])=[C:6]([B:8]([OH:10])[OH:9])[CH:7]=1.BrC1C=[C:18]([O:20]C)C=CC=1OC.[Li]CCCC.COB(OC)OC>>[CH3:12][O:11][C:5]1[CH:4]=[CH:3][C:2]([O:20][CH3:18])=[CH:7][C:6]=1[B:8]([OH:10])[OH:9]

참가 물질

5

반응물 4

HCID 8470Trimethyl borateHCID 91353Benzene, 2-bromo-1,4-dimethoxy-HCID 27826735-Fluoro-2-methoxyphenylboronic acidHCID 178418339Butyllithium

생성물 1

HCID 27343422,5-Dimethoxyphenylboronic acid수율 99%

실험 절차

This compound was prepared in a manner similar to that of 5-Fluoro-2-methoxyphenylboronic acid (EXAMPLE 107) from 1-bromo-2,5-dimethoxybenzene (2.00 mL, 13.3 mmol), n-BuLi (2.5 M in hexanes; 5.34 mL, 13.3 mmol), and trimethylborate (4.5 mL, 40 mmol) to afford 2.43 g (99%) of 2,5-dimethoxyphenylboronic acid which was used without further purification.

출처 및 근거

ORD 기록
ord-751b4c79d692484790fe287aa70cc713
출처 데이터셋
uspto-grants-2002_09
특허 번호
US06448405B1

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