N-(2-phenyl-phenylmethyl)-phthalimide → 1-Biphenyl-2-ylmethanamine

HRID 1280819

반응식

HRID 1280819 반응식
[C:1]1([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[CH2:13][N:14]2C(=O)C3=CC=CC=C3C2=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>O.NN>[C:1]1([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[CH2:13][NH2:14])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

3

반응물 1

HCID 18426122N-(2-phenyl-phenylmethyl)-phthalimide

생성물 1

HCID 2633661-Biphenyl-2-ylmethanamine수율 78.9%

시약·촉매·용매 1

HCID 24654Hydrazine hydrate (1:1)용매

실험 절차

N-(2-Phenyl-phenylmethyl)-phthalimide (6.5 g) in 25 cc of hydrazine hydrate were stirred at room temperature overnight. Ice water was added and the solid separated by filtration. The filtrate was salted out with brine and extracted with ethyl acetate. The ethyl acetate extract was washed with water, dried over magnesium sulfate, filtered and concentrated to dryness to afford 3 g of subtitled product as an oil.

후처리

  1. customthe solid separated by filtration
  2. extractionextracted with ethyl acetate
  3. extractionThe ethyl acetate extract
  4. washwas washed with water
  5. dry with materialdried over magnesium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-92513ac2ba0f4915b383c24c79517d71
출처 데이터셋
uspto-grants-2002_09
특허 번호
US06451839B1

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