Water → 5,6-Dicloro-1-(4-formylphenyl)benzimidazole

HRID 1281164

반응식

HRID 1281164 반응식
[Cl:1][C:2]1[C:10]([Cl:11])=[CH:9][C:5]2[N:6]=[CH:7][NH:8][C:4]=2[CH:3]=1.F[C:13]1[CH:20]=[CH:19][C:16]([CH:17]=[O:18])=[CH:15][CH:14]=1.C(=O)([O-])[O-].[K+].[K+].O>CS(C)=O>[Cl:11][C:10]1[C:2]([Cl:1])=[CH:3][C:4]2[N:8]([C:13]3[CH:20]=[CH:19][C:16]([CH:17]=[O:18])=[CH:15][CH:14]=3)[CH:7]=[N:6][C:5]=2[CH:9]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 680234-FluorobenzaldehydeHCID 3317755,6-Dichloro-1H-benzimidazole

생성물 1

HCID 184268625,6-Dicloro-1-(4-formylphenyl)benzimidazole수율 62%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

반응 조건

온도
100 °C

실험 절차

A mixture of 5,6-dichlorobenzimidazole (94 mg, 0.50 mmol), 4-fluorobenzaldehyde (0.064 mL, 0.60 mmol), and potassium carbonate (83 mg, 0.60 mmol) in dimethylsulfoxide (3 mL) was heated at 100° C. for 3 h. The mixture was cooled to room temperature, and water was added. The precipitated product was collected by filtration and washed with water and ethanol to afford 5,6-dicloro-1-(4-formylphenyl)benzimidazole (90 mg, 62%).

후처리

  1. temperatureThe mixture was cooled to room temperature
  2. filtrationThe precipitated product was collected by filtration
  3. washwashed with water and ethanol

출처 및 근거

ORD 기록
ord-77e0a820f50b4273b184d09f2092f214
출처 데이터셋
uspto-grants-2002_09
특허 번호
US06452014B1

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