Sodium Hydroxide → 2-Hydroxy-3-nitrobenzenecarbohydrazide

HRID 1281659노트

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HRID 1281659 반응식
O.[NH2:2][NH2:3].[N+:4]([C:7]1[CH:16]=[CH:15][CH:14]=[C:9]([C:10](OC)=[O:11])[C:8]=1[OH:17])([O-:6])=[O:5].[OH-].[Na+]>O1CCCC1>[OH:17][C:8]1[C:7]([N+:4]([O-:6])=[O:5])=[CH:16][CH:15]=[CH:14][C:9]=1[C:10]([NH:2][NH2:3])=[O:11]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 24654Hydrazine hydrate (1:1)HCID 596904Methyl 2-hydroxy-3-nitrobenzoate

생성물 1

HCID 113676062-Hydroxy-3-nitrobenzenecarbohydrazide수율 90%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

40 ml of hydrazine hydrate were added to a solution of 30 g (0.15 mol) of methyl 3-nitrosalicylate in 200 ml of anhydrous tetrahydrofuran (THF). After dilution with THF, the resulting suspension was stirrable; it was refluxed for approximately 18 hours. After cooling, the batch was poured onto ice. The aqueous solution was rendered neutral by adding NaOH solution. The crystals which precipitated were filtered off and washed with water. After drying, 27 g (90%) of the title compound were obtained.

후처리

  1. temperatureit was refluxed for approximately 18 hours
  2. temperatureAfter cooling
  3. additionthe batch was poured onto ice
  4. customThe crystals which precipitated
  5. filtrationwere filtered off
  6. washwashed with water
  7. customAfter drying

출처 및 근거

ORD 기록
ord-be80d6a2740b47469a8435481c37587a
출처 데이터셋
uspto-grants-2002_09
특허 번호
US06455515B2

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