Sodium Hydroxide → HCID 18422993, 화합물

HRID 1282186노트

반응식

HRID 1282186 반응식
[C:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[S:11][CH:12]=[CH:13][N:14]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[Br:15]N1C(=O)CCC1=O.[OH-].[Na+]>C(O)(=O)C>[C:1]([N:4]1[CH2:5][CH2:6][N:7]([C:10]2[S:11][C:12]([Br:15])=[CH:13][N:14]=2)[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 67184N-bromobutanimideHCID 18423162HCID 18423162, 화합물

생성물 1

HCID 18422993HCID 18422993, 화합물수율 68.1%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A solution of 4-acetyl-1-(thiazol-2-yl)piperazine (3.1 g) and N-bromosuccinimide (2.9 g) in acetic acid (14 ml) was stirred at room temperature for 1 hr. The reaction mixture was neutralized with 1N aqueous sodium hydroxide solution and extracted with ethyl acetate. The extract was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated to give a pale-brown solid (2.9 g). The obtained pale-brown solid was purified by silica gel column chromatography (developing solvent; chloroform:methanol=20:1) to give the title compound (2.1 g) as a pale-brown solid.

후처리

  1. extractionextracted with ethyl acetate
  2. washThe extract was washed with saturated brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-03f1bb9463d64664841c15e5acdee4b6
출처 데이터셋
uspto-grants-2002_09
특허 번호
US06455528B1

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