Sodium Hydroxide → 1-(5-Bromo-1,3-thiazol-2-yl)piperazine

HRID 1282187노트

반응식

HRID 1282187 반응식
C([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[S:11][C:12]([Br:15])=[CH:13][N:14]=2)[CH2:6][CH2:5]1)(=O)C.[OH-].[Na+]>Cl>[Br:15][C:12]1[S:11][C:10]([N:7]2[CH2:6][CH2:5][NH:4][CH2:9][CH2:8]2)=[N:14][CH:13]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 18422993HCID 18422993, 화합물

생성물 1

HCID 184230061-(5-Bromo-1,3-thiazol-2-yl)piperazine수율 87.7%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

4-Acetyl-1-(5-bromothiazol-2-yl)piperazine (2.0 g) was dissolved in 6N hydrochloric acid and refluxed under heating for 4.5 hr. The reaction mixture was neutralized with 1N aqueous sodium hydroxide solution and extracted with ethyl acetate. The extract was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated to give a brown oil (1.5 g). The obtained brown oil was purified by silica gel column chromatography (developing solvent; chloroform:methanol=9:1) to give the title compound (1.1 g) as a pale-yellow solid.

후처리

  1. temperaturerefluxed
  2. temperatureunder heating for 4.5 hr
  3. extractionextracted with ethyl acetate
  4. washThe extract was washed with saturated brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-7cb82f606874419db937c3a58d6b0fdb
출처 데이터셋
uspto-grants-2002_09
특허 번호
US06455528B1

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