Dimethyl Sulfoxide → 2-Cyano-2-(2-phenoxyphenyl)hexyl bromide

HRID 128223노트

반응식

HRID 128223 반응식
[O:1]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH:14]([CH2:17][CH2:18][CH2:19][CH3:20])[C:15]#[N:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Br:21][CH2:22]Br.CS(C)=O.[OH-].[Na+]>O>[C:15]([C:14]([C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[O:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)([CH2:17][CH2:18][CH2:19][CH3:20])[CH2:22][Br:21])#[N:16]

참가 물질

6

반응물 4

HCID 679Dimethyl SulfoxideHCID 3024DibromomethaneHCID 14798Sodium HydroxideHCID 197756142-(2-Phenoxyphenyl)hexanenitrile

생성물 1

HCID 234689402-Cyano-2-(2-phenoxyphenyl)hexyl bromide수율 82.3%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Into a three-necked 300 ml round bottom flask are charged 10 g (0.038 mole) of 2-(2-phenoxyphenyl)hexanenitrile, 6.6 g (0.038 mole) of dibromomethane and 50 ml of dimethyl sulfoxide. To this mixture with stirring is added 3.2 g (0.04 mole) of 50% sodium hydroxide solution dropwise. Reaction mixture is heated to give 60° for two hours and then poured into water and extracted with hexane. Combined hexane extracts are washed with water and dried over MgSO4. Solvent is evaporated under vacuum to give 11.2 g of product.

후처리

  1. customReaction mixture
  2. temperatureis heated
  3. customto give 60° for two hours
  4. extractionextracted with hexane
  5. washCombined hexane extracts are washed with water
  6. dry with materialdried over MgSO4
  7. customSolvent is evaporated under vacuum

출처 및 근거

ORD 기록
ord-a04fc54f54674e53baa7f7023a3030e8
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04259339

반응 노트

불러오는 중…