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Benzoyl chloride → 1-Benzoylimidazolidin-2-one

HRID 1283048
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HRID 1283048 반응식
[NH:1]1[CH2:5][CH2:4][NH:3][C:2]1=[O:6].O1CCCC1.[C:12](Cl)(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C([O-])(O)=O.[Na+]>C(Cl)(Cl)Cl>[C:12]([N:1]1[CH2:5][CH2:4][NH:3][C:2]1=[O:6])(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 7412Benzoyl chlorideHCID 8028Tetrahydrofuran2회HCID 84532-ImidazolidinoneHCID 516892Sodium Bicarbonate

생성물 1

HCID 5696651-Benzoylimidazolidin-2-one

시약·촉매·용매 1

HCID 6212Chloroform용매

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온도
10 °C

실험 절차

8.6 parts by weight of imidazolid-2-one in 100 parts by volume of dry tetrahydrofurane were treated with 15.5 parts by weight of benzoyl chloride in 30 parts by volume of tetrahydrofurane over the course of 15 minutes, at 5°-10°C, and the mixture was subsequently stirred for 3 hours at 10°C. The solvent was stripped off, the residue was shaken with a mixture of chloroform and aqueous NaHCO3 solution for 15 minutes, the chloroform was separated off, the water was again extracted with chloroform and the combined organic phases were washed with water, dried over MgSO4 and evaporated. The residue was recrystallized from ethyl acetate/ether.

후처리

  1. customthe chloroform was separated off
  2. extractionthe water was again extracted with chloroform
  3. washthe combined organic phases were washed with water
  4. dry with materialdried over MgSO4
  5. customevaporated
  6. customThe residue was recrystallized from ethyl acetate/ether

출처 및 근거

ORD 기록
ord-635e6ef9dab1460189d227c50aabfb3d
출처 데이터셋
uspto-grants-1976_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US03974142

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