Isoprene → 6-Methyl-6-hepten-2-one
반응식
P(Cl)(Cl)Cl.P(Br)(Br)Br.C(OCC)(=O)[CH2:10][C:11]([CH3:13])=[O:12].[CH2:18]=[CH:19][C:20](=[CH2:22])[CH3:21]>>[CH3:22][C:20](=[CH2:21])[CH2:19][CH2:18][CH2:10][C:11](=[O:12])[CH3:13]참가 물질
5
실험 절차
3,7,11-trimethyldodeca-1-yne-6,11-dien-3-ol can be obtained by halogenating 3-methyl-3-buten-1-ol, which is formed as a by-product in isoprene synthesis with phosphorus trichloride or phosphorus tribromide, reacting the halogenation product with ethyl acetoacetate to form 6-methyl-6-hepten-2-one, subjecting 6-methyl-6-hepten-2-one to ethynylation in the same manner as described above, thereafter subjecting the ethynylation product to partial hydrogenation in the presence of a Lindler catalyst, subjecting the partial hydrogenation product to Caroll rearrangement by using ethyl acetoacetate or diketene, and subjecting the rearrangement product to ethynylation.
출처 및 근거
- ORD 기록
- ord-1d878140c0e34ddd966cd2392d93d6e9
- 출처 데이터셋
- uspto-grants-1976_08
- 특허 번호
- US03975451
반응 노트
불러오는 중…