Hydrochloric Acid → Hydrochloric Acid

HRID 1283887

반응식

HRID 1283887 반응식
C[O:2][C:3]([C@@H:5]([NH2:12])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:4].[ClH:13]>>[CH:9]1[CH:8]=[CH:7][C:6]([C@H:5]([NH2:12])[C:3]([OH:4])=[O:2])=[CH:11][CH:10]=1.[ClH:13]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 1201451Methyl phenylglycinate, L-

생성물 2

HCID 313Hydrochloric AcidHCID 99291L-Phenylglycine

실험 절차

A solution of methyl L-phenylglycinate (-)-hemitartrate mono-ethanol solvate ([α]D + 62.4°, 36.888 g., 0.102 mole) in 6N-hydrochloric acid (68 ml., 0.408 mole, 4 equiv.) was refluxed for 1 hour 10 minutes and then distilled for 15 minutes. Water (68 ml.) was added and the pH of the warm solution adjusted to 7.0 with ammonium hydroxide solution (0.880, 35 ml.). The mixture was cooled in ice, filtered, and the solid was washed with water (2 × 25 ml.) and ethanol (25 ml.) and dried over phosphorus pentoxide to give L-phenylglycine as white plates (13.406 g., 87%), [α]D21 + 152.1° (c 1.007, 1N-HCl).

후처리

  1. distillationdistilled for 15 minutes
  2. additionWater (68 ml.) was added
  3. temperatureThe mixture was cooled in ice
  4. filtrationfiltered
  5. washthe solid was washed with water (2 × 25 ml.) and ethanol (25 ml.)
  6. dry with materialdried over phosphorus pentoxide

출처 및 근거

ORD 기록
ord-a0bc9825e8164839830096a5db6176ac
출처 데이터셋
uspto-grants-1976_08
특허 번호
US03976680

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