N-methyl-2-pyrrolidone → Dibenzofuran

HRID 128513

반응식

HRID 128513 반응식
CCO[CH:4]1N(C(OCC)=O)[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5]1.CCN(C(C)C)[CH:22]([CH3:24])[CH3:23].CN1C(=[O:34])CCC1>>[CH:8]1[C:7]2[C:6]3[CH:23]=[CH:22][CH:24]=[CH:4][C:5]=3[O:34][C:12]=2[CH:11]=[CH:10][CH:9]=1

참가 물질

4

반응물 3

HCID 13387N-methyl-2-pyrrolidoneHCID 278332-Ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinolineHCID 81531Diisopropylethylamine

생성물 1

HCID 568Dibenzofuran

실험 절차

Dbf-BAE (0.022 mmol), prepared above (F246), and EEDQ (0.024 mmol) are dissolved in NMP (0.3 mL). After 2 h of stirring at ambient temperature, N-glycylfluoresceinamine (0.022 mmol) and DIEA (0.012 mL, 0.067 mmol) are added as in examples 17 and 19 above. After about 18 h at ambient temperature, protected from light, the solvent is removed under reduced pressure and the residue purified by preparative TLC (reversed phase C18, 1 mm, methanol/500 mM NaCl, 6:4) giving the tracer shown below. ##STR15## D. Production of Antisera

후처리

  1. waitAfter about 18 h at ambient temperature
  2. customthe solvent is removed under reduced pressure
  3. customthe residue purified by preparative TLC (reversed phase C18, 1 mm, methanol/500 mM NaCl, 6:4)
  4. customgiving the tracer

출처 및 근거

ORD 기록
ord-8de111a5c3d9488bada670e47bf7ce9b
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05464746

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