Hydrochloric Acid → 4-(2-(Diethylamino)ethoxy)aniline

HRID 128620

반응식

HRID 128620 반응식
[CH2:1]([N:3]([CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][CH:10]=1)[CH2:4][CH3:5])[CH3:2].Cl.[OH-].[Na+]>O>[CH2:1]([N:3]([CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=1)[CH2:4][CH3:5])[CH3:2]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 88294Diethyl[2-(4-nitrophenoxy)ethyl]amine

생성물 1

HCID 4189324-(2-(Diethylamino)ethoxy)aniline

시약·촉매·용매 1

HCID 962Water용매

실험 절차

N,N-Diethyl-2-(4-nitrophenoxy)ethylamine (4.0 g) (prepared by the method described in Helv. Chim. Acta. 1960, 43, 1971) was dissolved in IMS (70 ml), water (10 ml) and concentrated hydrochloric acid (2 ml). The mixture was boiled under reflux and then reduced iron powder (4.6 g) was carefully added in portions. The mixture was boiled under reflux for 7 hours then hot filtered. The filtrate was basified with 5M sodium hydroxide solution and then evaporated under reduced pressure. The residue was partitioned between water and ether. The organic layer was separated, dried and evaporated to give 4-[2-(N,N-diethylamino)ethoxy]aniline as an oil.

후처리

  1. temperatureunder reflux
  2. temperatureunder reflux for 7 hours
  3. customevaporated under reduced pressure
  4. customThe residue was partitioned between water and ether
  5. customThe organic layer was separated
  6. customdried
  7. customevaporated

출처 및 근거

ORD 기록
ord-093748d8a4c444aba0ba587ee5938d8f
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05464781

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