Hydrochloric Acid → 6-Ethoxy-4-(4-methoxyanilino)-7-methyl-1,8-naphthyridine-3-carboxylic acid

HRID 128630

반응식

HRID 128630 반응식
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]2[C:11](=[N:12][C:13]=1[CH3:14])[N:10]=[CH:9][C:8]([C:15]([O:17]CC)=[O:16])=[C:7]2[NH:20][C:21]1[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=1)[CH3:2].[OH-].[Na+].Cl>O>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]2[C:11](=[N:12][C:13]=1[CH3:14])[N:10]=[CH:9][C:8]([C:15]([OH:17])=[O:16])=[C:7]2[NH:20][C:21]1[CH:22]=[CH:23][C:24]([O:27][CH3:28])=[CH:25][CH:26]=1)[CH3:2]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 9907935Ethyl 6-ethoxy-4-(4-methoxyanilino)-7-methyl-1,8-naphthyridine-3-carboxylate

생성물 1

HCID 193742766-Ethoxy-4-(4-methoxyanilino)-7-methyl-1,8-naphthyridine-3-carboxylic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture ethyl 6-ethoxy-4-(4-methoxyanilino)-7-methyl-1,8-naphthyridine-3-carboxylate (6.38 g), water (40 ml), sodium hydroxide solution (120 ml, 0.6M) was boiled and stirred under reflux for 2 hours and then allowed to cool. The mixture was acidified with 5M hydrochloric acid (100 ml) and filtered. The filtrate was extracted with dichloromethane to give a residue which was washed with 5M hydrochloric acid and filtered to give 6-ethoxy-4-(4-methoxyanilino)-7-methyl-1,8-naphthyridine-3-carboxylic acid, m.p. 259°-263° C.

후처리

  1. temperatureunder reflux for 2 hours
  2. temperatureto cool
  3. filtrationfiltered
  4. extractionThe filtrate was extracted with dichloromethane
  5. customto give a residue which
  6. washwas washed with 5M hydrochloric acid
  7. filtrationfiltered

출처 및 근거

ORD 기록
ord-46764644a2c54aa2b63e039efe1a4f11
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05464781

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