Acetone → 1-(4-Chlorophenyl)-3-octanimidoylurea

HRID 1287376노트

반응식

HRID 1287376 반응식
[Na].CC(C)=O.Cl.[C:7]([NH2:16])(=[NH:15])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([N:24]=[C:25]=[O:26])=[CH:20][CH:19]=1>C1C=CC=CC=1>[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([NH:24][C:25]([NH:15][C:7](=[NH:16])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])=[O:26])=[CH:20][CH:19]=1

참가 물질

6

반응물 4

HCID 180AcetoneHCID 76934-Chlorophenyl IsocyanateHCID 5360545SodiumHCID 86734052Octanamidine hydrochloride

생성물 1

HCID 1527468251-(4-Chlorophenyl)-3-octanimidoylurea

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

Following a procedure similar to that described in Example 1 but using 2.2 g. sodium in 200 ml. dry acetone, 17.8 g. octanamidine hydrochloride, and 15.3 g. 4-chlorophenyl isocyanate in 100 ml. benzene, there was obtained after recrystallization from acetonitrile 19.7 g. of the hydrochloride of 1-(4-chlorophenyl)-3-(octanimidoyl)urea; m.p. 156°-165°C.

후처리

  1. customafter recrystallization from acetonitrile 19.7 g

출처 및 근거

ORD 기록
ord-738c120d47aa40bfad1356532b655e4c
출처 데이터셋
uspto-grants-1976_10
특허 번호
US03984467

반응 노트

불러오는 중…