Sodium Hydroxide → (2E)-2-Methyl-7-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-heptenol

HRID 128786

반응식

HRID 128786 반응식
CC[O:3][C:4]([CH:6](P(OCC)(OCC)=O)[CH3:7])=O.[H-].[Na+].[CH3:18][C:19]1[CH2:24][CH2:23][CH2:22][C:21]([CH3:26])([CH3:25])[C:20]=1[CH2:27][CH2:28][CH2:29][CH2:30][CH:31]=O.C(=O)(O)[O-].[Na+].[H-].C([Al+]CC(C)C)C(C)C.[OH-].[Na+]>C1COCC1.C1(C)C=CC=CC=1>[CH3:7]/[C:6](=[CH:31]\[CH2:30][CH2:29][CH2:28][CH2:27][C:20]1[C:21]([CH3:25])([CH3:26])[CH2:22][CH2:23][CH2:24][C:19]=1[CH3:18])/[CH2:4][OH:3]

참가 물질

9

반응물 6

HCID 14798Sodium HydroxideHCID 24758Sodium hydrideHCID 107155Triethyl 2-phosphonopropionateHCID 516892Sodium BicarbonateHCID 193751545-(2,6,6-Trimethyl-1-cyclohexen-1-yl)pentanalHCID 21225700Diisobutylaluminumhydride

생성물 1

HCID 19375035(2E)-2-Methyl-7-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-heptenol수율 43.1%

시약·촉매·용매 2

HCID 1140Toluene용매HCID 8028Tetrahydrofuran용매

실험 절차

To a stirred solution of triethyl 2-phosphonopropionate (4.2 g) in THF (25 ml) under nitrogen is added sodium hydride (0.69 g of 60% dispersion in oil). After 30 minutes, 5-(2,6,6-trimethyl-1-cyclohexen-1-yl)pentanal (3.09 g) is added, and the mixture is stirred at reflux for16 hr. The reaction is cooled, poured into aqueous sodium bicarbonate, and extracted with ether. The extracts are concentrated and chromatographed with 30% dichloromethane in hexane to provide (2E)-2-methyl-7-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-heptenoic add ethyl ester as a colorless oil (2.4 g). This material (2.09 g) is reacted with diisobutylaluminum hydride (10 ml of 1.5M toluene solution) in toluene (20 ml) at -20° , stirred at 0° for 3 hr, then stirred for 16 hr with 1.0N sodium hydroxide solution. The mixture is extracted with ether, and the organic phase is concentrated and chromatographed with dichloromethane to provide 1.6 g of (2E)-2-methyl-7-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-heptenol as a colorless oil.

후처리

  1. temperatureat reflux for16 hr
  2. temperatureThe reaction is cooled
  3. extractionextracted with ether
  4. concentrationThe extracts are concentrated
  5. customchromatographed with 30% dichloromethane in hexane
  6. customto provide (2E)-2-methyl-7-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-heptenoic
  7. stirringstirred at 0° for 3 hr
  8. extractionThe mixture is extracted with ether
  9. concentrationthe organic phase is concentrated
  10. customchromatographed with dichloromethane

출처 및 근거

ORD 기록
ord-a201d8bc44424fc791242054bc5c15aa
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05464865

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