Hydrochloric Acid → 1-Chloro-5,5-dimethylnonan-4-one

HRID 1288338노트

반응식

HRID 1288338 반응식
[CH3:1][C:2]([Mg]Cl)([CH3:7])[CH2:3][CH2:4][CH2:5][CH3:6].[Mg].ClC(C)(C)CCCC.[Cl:19][CH2:20][CH2:21][CH2:22][C:23](Cl)=[O:24].Cl>CCOCC>[Cl:19][CH2:20][CH2:21][CH2:22][C:23](=[O:24])[C:2]([CH3:7])([CH3:1])[CH2:3][CH2:4][CH2:5][CH3:6]

참가 물질

7

반응물 5

HCID 313Hydrochloric AcidHCID 783704-Chlorobutyryl chlorideHCID 1382242-Chloro-2-methylhexaneHCID 5462224MagnesiumHCID 178443943HCID 178443943, 화합물

생성물 1

HCID 203860731-Chloro-5,5-dimethylnonan-4-one

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

Four hundred ml. of a solution in ether of 1,1-dimethylpentylmagnesium chloride prepared from magnesium (24.3 g, 1.0 mole) and 1-chloro-1,1-dimethylpentane (134.5 g., 1.0 mole) according to the procedure of Whitmore and Badertscher [J. Am. Chem. Soc., 55, 1559 (1933)] is added dropwise with stirring to 4-chlorobutyryl chloride (197 g., 1.4 moles) in ether (400 ml.) during 6 hours. The reaction mixture is stirred for an additional 12 hours. It is then poured into a mixture of ice and dilute hydrochloric acid. The ether layer is separated, washed with water and brine and dried over sodium sulfate. The ether is evaporated and the residue distilled at aspirator vacuum through a Vigreaux column to yield the product as a colorless oil.

후처리

  1. additionis added dropwise
  2. customThe ether layer is separated
  3. washwashed with water and brine
  4. dry with materialdried over sodium sulfate
  5. customThe ether is evaporated
  6. distillationthe residue distilled at aspirator vacuum through a Vigreaux column

출처 및 근거

ORD 기록
ord-436507d2322949cbb32d253106721048
출처 데이터셋
uspto-grants-1976_10
특허 번호
US03987091

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