Dimethyl Sulfoxide → 7,8-Dichloro-1-methylisoquinoline

HRID 1288477노트

반응식

HRID 1288477 반응식
[Cl:1][C:2]1[C:11]([Cl:12])=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[CH:9]2)=[CH:4][CH:3]=1.[CH3:13]S(C)=O.[H-].[Na+]>O>[Cl:1][C:2]1[C:11]([Cl:12])=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[C:9]2[CH3:13])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 679Dimethyl Sulfoxide2회HCID 24758Sodium hydrideHCID 125950627,8-Dichloroisoquinoline

생성물 1

HCID 213938347,8-Dichloro-1-methylisoquinoline

시약·촉매·용매 1

HCID 962Water용매2회

반응 조건

온도
70 °C

실험 절차

7,8-Dichloroisoquinoline (0.019 mole) in 100 ml. of dimethylsulfoxide is added to a solution of sodium hydride (0.11 mole) in 100 ml. of dimethylsulfoxide at 70° C. The reaction mixture is stirred at 70° C. for 4 hours under a nitrogen atmosphere. The reaction mixture is cooled, 100 ml. of water is added, and the mixture is poured into 1500 ml. of water. The aqueous mixture is extracted with benzene. The extract is washed, dried over sodium sulfate and evaporated to give 7,8-dichloro-1-methylisoquinoline.

후처리

  1. customat 70° C
  2. temperatureThe reaction mixture is cooled
  3. additionthe mixture is poured into 1500 ml
  4. extractionThe aqueous mixture is extracted with benzene
  5. washThe extract is washed
  6. dry with materialdried over sodium sulfate
  7. customevaporated

출처 및 근거

ORD 기록
ord-dd3e80d8e2844313aabb83c81a95059d
출처 데이터셋
uspto-grants-1976_10
특허 번호
US03988339

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