Hydrochloric Acid → Tetrahydropyranyl bromomethyl-cyclohexyl ether

HRID 1289350노트

반응식

HRID 1289350 반응식
[Br:1][CH2:2][CH:3]1[CH2:8][CH2:7][CH:6](O)[CH2:5][CH2:4]1.[O:10]1[CH:15]=[CH:14][CH2:13][CH2:12][CH2:11]1.Cl.C(=O)([O-])[O-:18].[K+].[K+]>>[Br:1][CH2:2][C:3]1([O:18][CH:15]2[CH2:14][CH2:13][CH2:12][CH2:11][O:10]2)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1

참가 물질

5

반응물 4

HCID 313Hydrochloric AcidHCID 80803,4-dihydro-2H-pyranHCID 11430Potassium CarbonateHCID 218327074-(Bromomethyl)cyclohexan-1-ol

생성물 1

HCID 21832708Tetrahydropyranyl bromomethyl-cyclohexyl ether

실험 절차

4-Bromomethylcyclohexanol (C-5) (3.0 g) and dihydropyran (2.6 g) were mixed together and cooled with ice. A tiny drop of 10% hydrochloric acid was added. Exothermic reaction occurred and stirred at ambient temperature overnight. The solution was neutralized with potassium carbonate and extracted with dichloromethane (50 ml). It was filtered and then dichloromethane from the filtrate was evaporated to yield the compound C-6, tetrahydropyranyl bromomethyl-cyclohexyl ether (5.0 g).

후처리

  1. temperaturecooled with ice
  2. customExothermic reaction
  3. extractionextracted with dichloromethane (50 ml)
  4. filtrationIt was filtered
  5. customdichloromethane from the filtrate was evaporated

출처 및 근거

ORD 기록
ord-8e0dbd93b09048068e94346ed1706d6b
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05750300

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