Tetrahydrofuran → 5-Amino-3-(4-chloro-1-naphthyl)-1-[methylamino(thiocarbonyl)]-1H-1,2,4-triazole

HRID 1289772노트

반응식

HRID 1289772 반응식
[NH2:1][C:2]1[N:6]=[C:5]([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]([Cl:17])=[CH:9][CH:8]=2)[NH:4][N:3]=1.[OH-].[Na+].[CH3:20][N:21]=[C:22]=[S:23].O1CCCC1>C(Cl)(Cl)Cl>[NH2:1][C:2]1[N:3]([C:22]([NH:21][CH3:20])=[S:23])[N:4]=[C:5]([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]([Cl:17])=[CH:9][CH:8]=2)[N:6]=1

참가 물질

6

반응물 4

HCID 8028TetrahydrofuranHCID 11167Methyl isothiocyanateHCID 14798Sodium HydroxideHCID 107528543-Amino-5-(4-chloro-1-naphthyl)-1H-1,2,4-triazol

생성물 1

HCID 105916075-Amino-3-(4-chloro-1-naphthyl)-1-[methylamino(thiocarbonyl)]-1H-1,2,4-triazole수율 5%

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

The synthesis method of Example 7-(3) was applied. The compound (2.19 g) obtained in (4) above, a 1N sodium hydroxide solution (10.0 ml), methyl isothiocyanate (1.38 g) and tetrahydrofuran (10 ml) were used as reagents. After the reaction, silica gel column chromatography (chloroform) and recrystallization from chloroform gave 135 mg of white crystals (yield 5% from methyl 4-chloro-1-naphthoate).

출처 및 근거

ORD 기록
ord-2974aa6beeca4219865fcf73d63b5b3e
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05750545

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