Acetic Acid → 2-Chloro-5-ethylpyridine

HRID 129101노트

반응식

HRID 129101 반응식
[N:1]1([CH:6]=[CH:7][C:8]#N)[CH2:5][CH2:4][CH2:3][CH2:2]1.N1(C=CCC)CCCC1.C(O)(=O)C.[ClH:23]>C(Cl)(Cl)Cl>[Cl:23][C:6]1[CH:7]=[CH:8][C:4]([CH2:3][CH3:2])=[CH:5][N:1]=1

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 1396491-But-1-enylpyrrolidineHCID 12732581beta-Pyrrolidino-acrylonitrile

생성물 1

HCID 111263632-Chloro-5-ethylpyridine

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

19.3 g of β-pyrrolidino-acrylonitrile were added at -10° C. to 30 g of pyrrolidino-butene from A4 in 50 ml of chloroform. The mixture was allowed to warmto RT, and 50 ml of acetic acid were added dropwise. After stirring at RT for 15 hours, the mixture was cooled to -10° C., and dry hydrogen chloride gas was introduced. Aqueous workup gave 2-chloro-5-ethylpyridine as the main product.

후처리

  1. customto warmto RT
  2. temperaturethe mixture was cooled to -10° C.

출처 및 근거

ORD 기록
ord-14b569afbedf4364a9df29d744aacb65
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05466800

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