Nimesulide → HCID 131720676, 화합물

HRID 1292322

반응식

HRID 1292322 반응식
[CH3:1][S:2]([NH:5][C:6]1[CH:7]=[CH:8][C:9]([N+:19]([O-:21])=[O:20])=[CH:10][C:11]=1[O:12][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)(=[O:4])=[O:3].[NH2:22][C@H:23]([C:29]([OH:31])=[O:30])[CH2:24][CH2:25][CH2:26][CH2:27][NH2:28].[CH2:32]([OH:119])[C@H:33]1[O:38][C@@H:37]2[O:39][C@H:40]3[C@H:45]([OH:46])[C@@H:44]([OH:47])[C@@H:43]([O:48][C@H:49]4[C@H:54]([OH:55])[C@@H:53]([OH:56])[C@@H:52]([O:57][C@H:58]5[C@H:63]([OH:64])[C@@H:62]([OH:65])[C@@H:61]([O:66][C@H:67]6[C@H:72]([OH:73])[C@@H:71]([OH:74])[C@@H:70]([O:75][C@H:76]7[C@H:81]([OH:82])[C@@H:80]([OH:83])[C@@H:79]([O:84][C@H:85]8[C@H:90]([OH:91])[C@@H:89]([OH:92])[C@@H:88]([O:93][C@H:94]9[C@H:100]([OH:101])[C@@H:99]([OH:102])[C@@H:97]([O:98][C@H:34]1[C@H:35]([OH:118])[C@H:36]2[OH:117])[O:96][C@@H:95]9[CH2:103][OH:104])[O:87][C@@H:86]8[CH2:105][OH:106])[O:78][C@@H:77]7[CH2:107][OH:108])[O:69][C@@H:68]6[CH2:109][OH:110])[O:60][C@@H:59]5[CH2:111][OH:112])[O:51][C@@H:50]4[CH2:113][OH:114])[O:42][C@@H:41]3[CH2:115][OH:116].CS(NC1C=CC([N+]([O-])=O)=CC=1OC1C=CC=CC=1)(=O)=O.N[C@H](C(O)=O)CCCCN>O>[CH3:1][S:2]([NH:5][C:6]1[CH:7]=[CH:8][C:9]([N+:19]([O-:21])=[O:20])=[CH:10][C:11]=1[O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)(=[O:3])=[O:4].[NH2:22][C@H:23]([C:29]([OH:31])=[O:30])[CH2:24][CH2:25][CH2:26][CH2:27][NH2:28].[CH2:107]([OH:108])[C@H:77]1[O:78][C@@H:79]2[O:84][C@H:85]3[C@H:90]([OH:91])[C@@H:89]([OH:92])[C@@H:88]([O:93][C@H:94]4[C@H:100]([OH:101])[C@@H:99]([OH:102])[C@@H:97]([O:98][C@H:34]5[C@H:35]([OH:118])[C@@H:36]([OH:117])[C@@H:37]([O:39][C@H:40]6[C@H:45]([OH:46])[C@@H:44]([OH:47])[C@@H:43]([O:48][C@H:49]7[C@H:54]([OH:55])[C@@H:53]([OH:56])[C@@H:52]([O:57][C@H:58]8[C@H:63]([OH:64])[C@@H:62]([OH:65])[C@@H:61]([O:66][C@H:67]9[C@H:72]([OH:73])[C@@H:71]([OH:74])[C@@H:70]([O:75][C@H:76]1[C@H:81]([OH:82])[C@H:80]2[OH:83])[O:69][C@@H:68]9[CH2:109][OH:110])[O:60][C@@H:59]8[CH2:111][OH:112])[O:51][C@@H:50]7[CH2:113][OH:114])[O:42][C@@H:41]6[CH2:115][OH:116])[O:38][C@@H:33]5[CH2:32][OH:119])[O:96][C@@H:95]4[CH2:103][OH:104])[O:87][C@@H:86]3[CH2:105][OH:106]

참가 물질

6

반응물 4

HCID 4495NimesulideHCID 5962L-LysineHCID 5287407gamma-CyclodextrinHCID 9825177HCID 9825177, 화합물

생성물 1

HCID 131720676HCID 131720676, 화합물

시약·촉매·용매 1

HCID 962Water용매2회

반응 조건

온도
50 °C

실험 절차

3 g of nimesulide (9.73×10-3 mole) are suspended in 200 ml of distilled water to which 3.2 g of L-lysine (1.95×10-2 mole) are added. The suspension is subjected to ultrasound for 5 minutes and then heated to 50° C. while violent agitation is maintained [Ultraturrax (registered mark)]. 13.88 g of γ-CD·7H2O (9.73×10-3 mole) are dispersed in 200 ml of distilled water and heated to 50° C. The suspension of γ-CD is added to the suspension of nimesulide+L-lysine. The agitation is continued for 15 minutes. An orangy solution is obtained. This solution is nebulized (Niro Atomizer Mobile atomizer) in the following conditions:

후처리

  1. additionare added
  2. temperatureis maintained [Ultraturrax (registered mark)]
  3. temperatureheated to 50° C
  4. waitThe agitation is continued for 15 minutes
  5. customAn orangy solution is obtained

출처 및 근거

ORD 기록
ord-d52e7b91cb6d438493a11dc42c25e99b
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05756546

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