Acetic Acid → N-Acetyl-L-proline

HRID 1292328

반응식

HRID 1292328 반응식
[S-][C:2]#[N:3].[NH4+].[C:5]([OH:8])(=[O:7])[CH3:6].F[C:10](F)(F)[C:11]([OH:13])=O.[C:16](OC(=O)C)(=O)[CH3:17]>C(N(CC)CC)C>[C:11]([N:3]1[CH2:2][CH2:17][CH2:16][C@H:6]1[C:5]([OH:8])=[O:7])(=[O:13])[CH3:10]

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 6422Trifluoroacetic acidHCID 7918Acetic AnhydrideHCID 15666Ammonium thiocyanate

생성물 1

HCID 66141N-Acetyl-L-proline

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

ammonium thiocyanate (BDH, Analar), Aristar acetic acid (BDH), eptide synthesis grades of trifluoroacetic acid and acetic anhydride (Applied Biosystems) were used without further purification. Reagents for amino acid analysis of phenylthiocarbamyl amino acids were all of the highest possible purity (Inglis et al Biochem. Biophys. Methods 15:249, 1988). Pierce 6M constant boiling HC1 and Analar phenol (BDH) were used for hydrolysis and N,N-diisopropylethylamine (DIEA, Peptide Synthesis Grade, Applied Biosystems) replaced triethylamine in the drying reagent and in the coupling buffer.

후처리

  1. customwere used without further purification
  2. customand Analar phenol (BDH) were used for hydrolysis and N,N-diisopropylethylamine (DIEA, Peptide Synthesis Grade, Applied Biosystems)

출처 및 근거

ORD 기록
ord-34e412f94b714d90839c31b45566e546
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05756667

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