Carbon tetrabromide → 4-(1-Bromoethyl)benzonitrile

HRID 1292686노트

반응식

HRID 1292686 반응식
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9](O)[CH3:10])=[CH:5][CH:4]=1)#[N:2].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:32]>C(OCC)C>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]([Br:32])[CH3:10])=[CH:5][CH:4]=1)#[N:2]

참가 물질

5

반응물 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 5833354-(1-Hydroxyethyl)benzonitrile

생성물 1

HCID 218346374-(1-Bromoethyl)benzonitrile

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To a solution of 1-(4-Cyanophenyl)ethanol 1.01 g, 6.84 mmol), in diethyl ether (15 ml) and triphenylphosphine (2.14 g, 8.17 mmol), was added carbon tetrabromide (2.82 g, 8.50 mmol) in dieathylether (20 ml) at room temperature. After 30 min the reaction was filtered through celite and evaporated to dryness. The residue was purified by chromatography (SiO2, 5% EtOAc in hexanes) to afford the title compound as an oil

후처리

  1. filtrationAfter 30 min the reaction was filtered through celite
  2. customevaporated to dryness
  3. customThe residue was purified by chromatography (SiO2, 5% EtOAc in hexanes)

출처 및 근거

ORD 기록
ord-8400164f6e6e4528b670fc56db847540
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05756528

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