Hydrogen Peroxide → 1-(Isopropylsulfonyl)propan-2-one

HRID 129375

반응식

HRID 129375 반응식
[CH3:1][CH:2]([SH:4])[CH3:3].[OH-:5].[K+].Cl[CH2:8][C:9](=[O:11])[CH3:10].[OH:12]O>C(O)C.[O-][W]([O-])(=O)=O.[Na+].[Na+]>[CH3:1][CH:2]([S:4]([CH2:8][C:9]([CH3:10])=[O:11])(=[O:12])=[O:5])[CH3:3]

참가 물질

7

반응물 4

HCID 784Hydrogen PeroxideHCID 63642-PropanethiolHCID 6571ChloroacetoneHCID 14797Potassium Hydroxide

생성물 1

HCID 229086371-(Isopropylsulfonyl)propan-2-one수율 71.9%

시약·촉매·용매 2

HCID 26052Sodium tungstate촉매HCID 702Ethanol용매

실험 절차

To 2-propanethiol (12.2 g, 0.16 mole), a solution of potassium hydroxide (11.5 g, 0.174 mole) in ethanol (100 ml) was added dropwise at 15° C. or lower, and continued to stir at the same temperature for 24 hours. Then chloroacetone (23.1 g, 0.25 mole) was added dropwise at 10°-15° C., and reacted with stirring at 20° C. for 4 hours. To this mixture, sodium tungstate (0.8 g) was added, 30% hydrogen peroxide (36 g, 0.32 mole) was added dropwise at 45°-55° C., and reacted with stirring at room temperature for 14 hours. The reaction mixture was extracted with methylene chloride (200 ml). The organic layer was washed with H2O, dried over anhydrous MgSO4 and evaporated to give 18.9 g of residual crude 1-(1-methylethylsulfonyl)acetone as a brownish yellow oil.

후처리

  1. customreacted
  2. stirringwith stirring at 20° C. for 4 hours
  3. customreacted
  4. stirringwith stirring at room temperature for 14 hours
  5. extractionThe reaction mixture was extracted with methylene chloride (200 ml)
  6. washThe organic layer was washed with H2O
  7. dry with materialdried over anhydrous MgSO4
  8. customevaporated

출처 및 근거

ORD 기록
ord-cd3cc7551858402b927a8ff0ae3afcfc
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05468589

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