Sodium borohydride → 9-Hydroxy-9H-indeno[1,2-b]pyrazin-3(4H)-one

HRID 129447

반응식

HRID 129447 반응식
[N:1]1[C:2]2[C:14](=[O:15])[C:13]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[C:3]=2[NH:4][C:5](=[O:7])[CH:6]=1.[BH4-].[Na+]>>[OH:15][CH:14]1[C:2]2[N:1]=[CH:6][C:5](=[O:7])[NH:4][C:3]=2[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:13]1=2

참가 물질

3

반응물 2

HCID 4311764Sodium borohydrideHCID 190359769H-Indeno[1,2-b]pyrazine-3,9(4H)-dione

생성물 1

HCID 190359849-Hydroxy-9H-indeno[1,2-b]pyrazin-3(4H)-one수율 104.7%

실험 절차

9H-Indeno[1,2-b]pyrazine-3,9(4H)-dione (5.0 g, 25.23 mmol) was reduced with sodium borohydride (1.72 g, 45.5 mmol) as described in example 11. Yield 5.29 g (96%) of the title compound. M.p. 251°-253° C. 1H-NMR (DMSO-d6, δ): 5.32 (d, 1H), 5.92 (d, 1H), 7.47 (m, 2H), 7.64 (m, 1H), 7.8 (m, 1H), 7.9 (s, 1H), 12.5 (s, 1H).

출처 및 근거

ORD 기록
ord-d25e5f7fb3b245278ffad42b6d1f0464
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05468748

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