Methyl iodide → HCID 19371363, 화합물

HRID 129541노트

반응식

HRID 129541 반응식
[H-].[Na+].[CH3:3][C:4]([CH3:16])([C:6](=[O:15])[CH:7]([CH3:14])[C:8](=[O:13])[C:9]([CH3:12])([CH3:11])[CH3:10])[CH3:5].[CH3:17]I>O1CCCC1>[CH3:10][C:9]([CH3:12])([C:8](=[O:13])[C:7]([CH3:17])([CH3:14])[C:6](=[O:15])[C:4]([CH3:3])([CH3:16])[CH3:5])[CH3:11]

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 2315862,2,4,6,6-pentamethylheptane-3,5-dione

생성물 1

HCID 19371363HCID 19371363, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a suspension of 1.6 g of NaH at 80% by weight in 42 ml of anhydrous tetrahydrofurane are added dropwise 8 g of 2,2,4,6,6-pentamethyl-3,5-heptanedione (0.04 moles). The content is stirred at ambient temperature until a homogeneous solution is obtained. 7.7 ml of methyl iodide are then added and a white precipitate forms almost immediately. The content is allowed to agitate at ambient temperature for 12 hours and then the solvent is evaporated. Some water is added (10 ml) and the content is extracted with ether and then anhydrated on Na2SO4. The ether is evaporated to the rotavapor, isolating a white needle-shaped solid, which is then purified by way of sublimation.

후처리

  1. customis obtained
  2. stirringto agitate at ambient temperature for 12 hours
  3. customthe solvent is evaporated
  4. additionSome water is added (10 ml)
  5. extractionthe content is extracted with ether
  6. customThe ether is evaporated to the rotavapor
  7. customisolating a white needle-shaped solid, which
  8. customis then purified by way of sublimation

출처 및 근거

ORD 기록
ord-c5707755485c42bd9fe11d595d0c79c4
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05468704

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