Sodium Chloride → 4-(2,4,5-Trifluoro-phenoxy)butan-1-ol

HRID 1295718

반응식

HRID 1295718 반응식
[CH2:1]([OH:6])[CH2:2][CH2:3][CH2:4][OH:5].CC([O-])(C)C.[K+].[F:13][C:14]1[CH:19]=[C:18]([F:20])[C:17]([F:21])=[CH:16][C:15]=1F.[Cl-].[Na+]>O.C1(C)C=CC=CC=1.CS(C)=O>[F:13][C:14]1[CH:19]=[C:18]([F:20])[C:17]([F:21])=[CH:16][C:15]=1[O:5][CH2:4][CH2:3][CH2:2][CH2:1][OH:6]

참가 물질

8

반응물 4

HCID 5234Sodium ChlorideHCID 80641,4-ButanediolHCID 94741,2,4,5-TetrafluorobenzeneHCID 23665647Potassium tert-butoxide

생성물 1

HCID 693646634-(2,4,5-Trifluoro-phenoxy)butan-1-ol

시약·촉매·용매 3

HCID 679Dimethyl Sulfoxide용매HCID 962Water용매HCID 1140Toluene용매

실험 절차

To a mixture of 1,4-butanediol (15 g, 0.17 mol) and t-BuOK (8.0 g, 0.071 mol) were added 1,2,4,5-tetrafluorobenzene (5.0 g, 33 mmol) and DMSO (50 g) at 60° C. After being stirred at this temperature for 18 h, toluene (200 mL), water (50 mL) and sodium chloride (10 g) were added to the reaction mixture. The layers were separated and the organic layer was concentrated in vacuo giving the title compound. This material was used directly in the next step.

후처리

  1. customThe layers were separated
  2. concentrationthe organic layer was concentrated in vacuo

출처 및 근거

ORD 기록
ord-663d6016ba36490f8673a3c4952bbb51
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07244722B2

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