4-Methoxyphenylacetic Acid → 1-(2,4-Dihydroxy-3-methylphenyl)-2-(4-methoxyphenyl)ethanone

HRID 1296946

반응식

HRID 1296946 반응식
[CH3:1][C:2]1[C:8]([OH:9])=[CH:7][CH:6]=[CH:5][C:3]=1[OH:4].[CH3:10][O:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][C:19](O)=[O:20])=[CH:14][CH:13]=1.B(F)(F)F.CCOCC>>[OH:4][C:3]1[C:2]([CH3:1])=[C:8]([OH:9])[CH:7]=[CH:6][C:5]=1[C:19](=[O:20])[CH2:18][C:15]1[CH:16]=[CH:17][C:12]([O:11][CH3:10])=[CH:13][CH:14]=1

참가 물질

4

반응물 3

HCID 76904-Methoxyphenylacetic AcidHCID 8000Boron trifluoride etherateHCID 118432-Methylresorcinol

생성물 1

HCID 155208501-(2,4-Dihydroxy-3-methylphenyl)-2-(4-methoxyphenyl)ethanone

실험 절차

A solution of 2-methyl resorcinol (1 eq) and p-methoxy phenyl acetic acid (1 eq) in boron trifluoride diethyl etherate (8 eq) was refluxed for 3½ h, whilst stirring, under nitrogen. The brown solution was allowed to cool to room temperature, quenched with NaOAc solution (10% w/v) and left to stand overnight. The resultant precipitate was filtered, washed with water and dried to give 1-(2,4-dihydroxy-3-methyl-phenyl)-2-(4-methoxy-phenyl)-ethanone as a solid.

후처리

  1. customquenched with NaOAc solution (10% w/v)
  2. waitleft
  3. filtrationThe resultant precipitate was filtered
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-984a19e1af6945558723cf2dfd6ebb34
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07247734B2

연결된 노트

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