Triethyl phosphite → Diethyl (Methoxymethyl)phosphonate

반응식

C([O:3][P:4]([O:8][CH2:9][CH3:10])[O:5][CH2:6][CH3:7])C.[CH3:11][O:12][CH2:13]Br>>[CH3:11][O:12][CH2:13][P:4](=[O:3])([O:5][CH2:6][CH3:7])[O:8][CH2:9][CH3:10]

참가 물질

반응물 2

HCID 31215Triethyl phosphite

HCID 83093Bromomethyl methyl ether

생성물 1

HCID 11658394Diethyl (Methoxymethyl)phosphonate수율 98%

실험 절차

To a sample of 17.90 mL (0.104 mol) of triethylphosphite at -78° C. under argon was added dropwise 8.50 mL (0.104 mol) of bromomethyl methyl ether. The mixture slowly warmed to RT and stirred for 24 h, when it was fractionally distilled (bp 100° C., 5 mm) to provide 16.22 g (98%) of title compound as a pale yellow oil.

후처리

distillationwhen it was fractionally distilled (bp 100° C., 5 mm)

출처 및 근거

ORD 기록: ord-b9f3818a0f834bd892592a8c40680371
출처 데이터셋: uspto-grants-1995_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05470845

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