Diisopropylamine → 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite

HRID 130285

반응식

HRID 130285 반응식
[Cl:1][P:2](Cl)[O:3][CH2:4][CH2:5][C:6]#[N:7].[CH:9]([N:12]([CH:15]([CH3:17])[CH3:16])CC)([CH3:11])[CH3:10].C(NC(C)C)(C)C>ClCCl.CN(C1C=CN=CC=1)C>[CH:9]([N:12]([P:2]([Cl:1])[O:3][CH2:4][CH2:5][C:6]#[N:7])[CH:15]([CH3:17])[CH3:16])([CH3:11])[CH3:10]

참가 물질

6

반응물 3

HCID 7912DiisopropylamineHCID 81531DiisopropylethylamineHCID 195897beta-Cyanoethyl phosphorodichloridite

생성물 1

HCID 27348442-Cyanoethyl N,N-diisopropylchlorophosphoramidite

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 6344Dichloromethane용매

실험 절차

To a solution of 0.54 mL(4.0 mmol) of dichloro(β-cyano)ethoxyphosphine in 40 mL of dichloromethane cooled in an ice-water bath was added 10 mL of diisopropylethylamine, followed by adding 0.64 mL (4.0 mmol) of diisopropylamine under Argon. The reaction mixture was warmed up to room temperature and stirred for 2 h. After adding 0.1 gm of DMAP into the solution, the reaction mixture is ready for the next step reaction.

후처리

  1. customthe reaction mixture is ready for the next step reaction

출처 및 근거

ORD 기록
ord-1f09ddb2ebd64198839d633289cfe614
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07381533B2

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