Cyanoacetamide → 2-Cyano-2-cyclohexylidene-acetamide

반응식

[C:1]1(=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:8]([CH2:10][C:11]([NH2:13])=[O:12])#[N:9]>>[C:1]1(=[C:10]([C:8]#[N:9])[C:11]([NH2:13])=[O:12])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

반응물 2

HCID 7898Cyanoacetamide

HCID 7967Cyclohexanone

생성물 1

HCID 2636542-Cyano-2-cyclohexylidene-acetamide

실험 절차

Reaction 1. consists of condensing the cyclohexanone (I) with cyanoacetamide, to obtain 2-cyclohexylidene-2-cyanoacetamide (IX); this reaction can be undertaken for example in toluene, in the presence of ammonium acetate and acetic acid, heating to a temperature between 20 and 150° C., and preferably to the reflux temperature of the reaction mixture; the compound IX is separated from the reaction mixture.

후처리

customReaction 1

출처 및 근거

ORD 기록: ord-4850e2d858e9406fbd9625fdcdfcc579
출처 데이터셋: uspto-grants-2008_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07381823B2

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