2-Methyl-3-nitroaniline → 4-Iodo-2-methyl-3-nitrobenzenamine

HRID 132408

반응식

HRID 132408 반응식
[CH3:1][C:2]1[C:8]([N+:9]([O-:11])=[O:10])=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].C(=O)([O-])O.[Na+].[I:17]Cl>CO>[I:17][C:7]1[CH:6]=[CH:5][C:3]([NH2:4])=[C:2]([CH3:1])[C:8]=1[N+:9]([O-:11])=[O:10]

참가 물질

5

반응물 3

HCID 117832-Methyl-3-nitroanilineHCID 24640Iodine chlorideHCID 516892Sodium Bicarbonate

생성물 1

HCID 597319804-Iodo-2-methyl-3-nitrobenzenamine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a well stirred solution of 2-methyl-3-nitroaniline (10 g, 66 mmol) in methanol (150 mL) was added sodium hydrogencarbonate (264 mmol) followed by 1.0 M solution of iodine monochloride (72 mmol) at room temperature. After stirring for 1 h, the solvent was removed, diluted with ether, washed with 10% aqueous sodium thiosulfate solution. The solvent was removed and the crude iodide was in the next step.

후처리

  1. customthe solvent was removed
  2. additiondiluted with ether
  3. washwashed with 10% aqueous sodium thiosulfate solution
  4. customThe solvent was removed

출처 및 근거

ORD 기록
ord-2bc134c838a349289d9037fc279b9ce1
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07384931B2

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