Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

HRID 1325598노트

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HRID 1325598 반응식
C1COCCN1.FC(F)(F)c1ccc(Br)cc1>CC(C)(C)[O-].COCCOCCOC.CS(C)=O.[Cl-].[Cl][Cu].[Na+].c1ccc2c(c1)n(C1CCCCC1)c[n+]2C1CCCCC1>FC(F)(F)c1ccc(N2CCOCC2)cc1

참가 물질

10

반응물 2

HCID 8083MorpholineHCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-

생성물 3

HCID 2519CaffeineHCID 109333104-(4-Trifluoromethylphenyl)morpholine수율 1.27%HCID 154202994-(3-(Trifluoromethyl)phenyl)morpholine수율 0%

시약·촉매·용매 5

HCID 23676156Sodium t-butoxide시약HCID 62652Cuprous chloride촉매HCID 162182671,3-Dicyclohexyl-1H-benzimidazol-3-ium chloride촉매HCID 679Dimethyl Sulfoxide용매5회HCID 8150Diglyme용매5회

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온도
60 °C

후처리

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid 상 유지
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

출처 및 근거

ORD 기록
ord-caef00bd086d4001888897c47cf44805
출처 데이터셋
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
원본 링크
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