Hydrochloric Acid → 5-Acetyl-1,3-benzoxazol-2(3H)-one

HRID 132679

반응식

HRID 132679 반응식
C(N(CC)CC)C.ClC(Cl)(O[C:12](=[O:18])[O:13][C:14](Cl)(Cl)Cl)Cl.[NH2:20][C:21]1[CH:26]=[C:25]([C:27]([CH3:29])=[O:28])[CH:24]=[CH:23]C=1O.Cl>C1COCC1>[CH3:29][C:27]([C:25]1[CH:24]=[CH:23][C:14]2[O:13][C:12](=[O:18])[NH:20][C:21]=2[CH:26]=1)=[O:28]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 94429TriphosgeneHCID 137241423'-Amino-4'-hydroxyacetophenone

생성물 1

HCID 151135715-Acetyl-1,3-benzoxazol-2(3H)-one

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

7.8 ml of triethylamine and 2.75 g (0.0093 mol) of triphosgene are added to a mixture of 4.2 g (0.0277 mol) of 2-amino-4-methylcarbonylphenol in 100 ml of THF, at 0° C. The mixture is stirred at room temperature for 1 hour, poured into 100 ml of a 0.5N HCl solution and extracted with ethyl acetate, the organic phase is dried and the solvent is evaporated off. The compound of the title is obtained.

후처리

  1. extractionextracted with ethyl acetate
  2. customthe organic phase is dried
  3. customthe solvent is evaporated off
  4. customThe compound of the title is obtained

출처 및 근거

ORD 기록
ord-4bcf49dca56c44ff98bc5112ba8c17d6
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07388031B2

연결된 노트

불러오는 중…