Hydrazine hydrate (1:1) → 3-Fluoro-4-phenylmethoxyaniline

HRID 13323노트

반응식

HRID 13323 반응식
O.NN.[CH2:4]([O:11][C:12]1[CH:17]=[CH:16][C:15]([N+:18]([O-])=O)=[CH:14][C:13]=1[F:21])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>[Ni].CO>[CH2:4]([O:11][C:12]1[CH:17]=[CH:16][C:15]([NH2:18])=[CH:14][C:13]=1[F:21])[C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1

참가 물질

5

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 220309121-(Benzyloxy)-2-fluoro-4-nitrobenzene

생성물 1

HCID 219518923-Fluoro-4-phenylmethoxyaniline

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

2.91 ml of hydrazine monohydrate and about 1 g of developed Raney nickel catalyst were added to a methanol (60 ml) solution of 4.94 g of 4-benzyloxy-3-fluoronitrobenzene, and the reaction liquid was stirred at room temperature for 2 hours. The catalyst was removed through filtration through Celite, and the solvent was evaporated away under reduced pressure to obtain the entitled compound as a yellow oily substance.

후처리

  1. customthe reaction liquid
  2. customThe catalyst was removed through filtration through Celite
  3. customthe solvent was evaporated away under reduced pressure
  4. customto obtain the entitled compound as a yellow oily substance

출처 및 근거

ORD 기록
ord-8a7b2fe512ff448ba96e29c11a108f22
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728025B2

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