Dimethylformamide → N-(4-benzyloxy-5-(2-fluorophenoxy)-2-nitrophenyl)pyrazinecarboxamide

HRID 13326

반응식

HRID 13326 반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].C(=O)([O-])[O-].[K+].[K+].CN(C)C=O.[CH2:20]([O:27][C:28]1[C:33](F)=[CH:32][C:31]([NH:35][C:36]([C:38]2[CH:43]=[N:42][CH:41]=[CH:40][N:39]=2)=[O:37])=[C:30]([N+:44]([O-:46])=[O:45])[CH:29]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>O>[CH2:20]([O:27][C:28]1[C:33]([O:8][C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[F:1])=[CH:32][C:31]([NH:35][C:36]([C:38]2[CH:43]=[N:42][CH:41]=[CH:40][N:39]=2)=[O:37])=[C:30]([N+:44]([O-:46])=[O:45])[CH:29]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 97072-FluorophenolHCID 11430Potassium CarbonateHCID 23145743N-(4-benzyloxy-5-fluoro-2-nitrophenyl)pyrazinecarboxamide

생성물 1

HCID 23145658N-(4-benzyloxy-5-(2-fluorophenoxy)-2-nitrophenyl)pyrazinecarboxamide

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
90 °C

실험 절차

0.54 ml of 2-fluorophenol and 2.53 g of potassium carbonate were added to a dimethylformamide (16 ml) solution of 2.14 g of N-(4-benzyloxy-5-fluoro-2-nitrophenyl)pyrazinecarboxamide, and the reaction liquid was stirred at 90° C. for 5 hours, and then water was added to it. The resulting deposit was taken out through filtration to obtain the entitled compound as a yellow solid.

후처리

  1. customthe reaction liquid
  2. filtrationThe resulting deposit was taken out through filtration

출처 및 근거

ORD 기록
ord-76da9412acef46d08b316ba9c7c4c87c
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728025B2

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