Methyl pyruvate → N-(3,4-methylenedioxyphenyl)alanine Iso-butyl Ester

HRID 133340

반응식

HRID 133340 반응식
C1O[C:9]2C=CC(N)=[CH:4][C:3]=2O1.C(OC)(=O)C(C)=O.[CH3:18][O:19][C:20](=[O:33])[C@H:21]([CH3:32])[NH:22][C:23]1[CH:28]=[CH:27][C:26]2[O:29][CH2:30][O:31][C:25]=2[CH:24]=1>C(O)C(C)C>[CH2:18]([O:19][C:20](=[O:33])[C@H:21]([CH3:32])[NH:22][C:23]1[CH:28]=[CH:27][C:26]2[O:29][CH2:30][O:31][C:25]=2[CH:24]=1)[CH:3]([CH3:4])[CH3:9]

참가 물질

5

반응물 3

HCID 11748Methyl pyruvateHCID 843101,3-Benzodioxol-5-amineHCID 54531586N-(3,4-methylenedioxyphenyl)alanine methyl ester

생성물 1

HCID 54134455N-(3,4-methylenedioxyphenyl)alanine Iso-butyl Ester

시약·촉매·용매 1

HCID 6560Isobutanol용매

실험 절차

Following reductive amination General Procedure AA above and using 3,4-methylenedioxyaniline (Aldrich) and methyl pyruvate (Aldrich), N-(3,4-methylenedioxyphenyl)alanine methyl ester was prepared. The methyl ester was then transesterified following General Procedure AQ above and using iso butanol to provide the title compound as an oil. The reaction was monitored by silica gel dc (Rf=0.61 in 25% EtOAc/hexanes). Purification was by preparative plate chromatography with silica gel using 25% EtOAc/hexanes as the eluant.

후처리

  1. customwas prepared

출처 및 근거

ORD 기록
ord-12e04e799171427d96503c1f1f1c2440
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07390801B2

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