HCID 22270443, 화합물 → HCID 22270357, 화합물

HRID 133449노트

반응식

HRID 133449 반응식
[N:1]([CH:4]([CH:6]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:7][CH:8]([CH3:10])[CH3:9])[CH3:5])=[N+]=[N-]>CO.Cl.O=[Pt]=O>[NH2:1][CH:4]([CH:6]([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[CH2:7][CH:8]([CH3:10])[CH3:9])[CH3:5]

참가 물질

5

반응물 1

HCID 22270443HCID 22270443, 화합물

생성물 1

HCID 22270357HCID 22270357, 화합물

시약·촉매·용매 3

HCID 313Hydrochloric Acid촉매HCID 345198Adams' catalyst촉매HCID 887Methanol용매

실험 절차

To a solution of 32 mg 2-azido-5-methyl-3-phenylhexane in 1 mL MeOH and 2 drops of 1.2 N HCl, 4 mg PtO2 was added and the solution was stirred under H2 atmosphere for 2 h. The reaction was filtered through a pad of CELITE diatomaceous earth and the pad was rinsed with MeOH. The combined filtrate was concentrated to give the desired product. 1H NMR: (500 MHz, CDCl3): δ 0.86 (m, 6H), 0.99 (d, 3H), 1.25 (m, 1H), 1.54 (m, 1H), 1.77 (m, 1H), 2.73 (m, 1H), 3.19 (m, 1H), 7.2-7.4 (m, 5H).

후처리

  1. filtrationThe reaction was filtered through a pad of CELITE diatomaceous earth
  2. washthe pad was rinsed with MeOH
  3. concentrationThe combined filtrate was concentrated

출처 및 근거

ORD 기록
ord-ffeda3a5363f4bc19cf3e280e11a2322
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07390835B2

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