4-Bromoaniline → (4-Bromophenyl)(5-methoxybenzoxazol-2-yl)amine
반응식
Cl[C:2]1[O:3][C:4]2[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:5]=2[N:6]=1.[Br:13][C:14]1[CH:20]=[CH:19][C:17]([NH2:18])=[CH:16][CH:15]=1.C(N(C(C)C)CC)(C)C>CN(C)C=O>[Br:13][C:14]1[CH:20]=[CH:19][C:17]([NH:18][C:2]2[O:3][C:4]3[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:5]=3[N:6]=2)=[CH:16][CH:15]=1참가 물질
5
실험 절차
The mixture containing 2-chloro-5-methoxybenzoxazole (1 eq), 4-bromoaniline (2 eq) and diisopropylethylamine was refluxed in dimethylformamide. The resultant mixture was concentrated and partitioned between ethyl acetate and water. The organic layer was washed with brine and dried. Purification on silica gel gave (4-bromophenyl)(5-methoxybenzoxazol-2-yl)amine. MS: MH+=318
후처리
- concentrationThe resultant mixture was concentrated
- custompartitioned between ethyl acetate and water
- washThe organic layer was washed with brine
- customdried
- customPurification on silica gel
출처 및 근거
- ORD 기록
- ord-9bac4797f8dc4d1cae695a5979e23f2d
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07728010B2
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