4-Bromoaniline → (4-Bromophenyl)(5-methoxybenzoxazol-2-yl)amine

HRID 13455

반응식

HRID 13455 반응식
Cl[C:2]1[O:3][C:4]2[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:5]=2[N:6]=1.[Br:13][C:14]1[CH:20]=[CH:19][C:17]([NH2:18])=[CH:16][CH:15]=1.C(N(C(C)C)CC)(C)C>CN(C)C=O>[Br:13][C:14]1[CH:20]=[CH:19][C:17]([NH:18][C:2]2[O:3][C:4]3[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:5]=3[N:6]=2)=[CH:16][CH:15]=1

참가 물질

5

반응물 3

HCID 78074-BromoanilineHCID 81531DiisopropylethylamineHCID 118197122-Chloro-5-methoxy-1,3-benzoxazole

생성물 1

HCID 22040817(4-Bromophenyl)(5-methoxybenzoxazol-2-yl)amine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

The mixture containing 2-chloro-5-methoxybenzoxazole (1 eq), 4-bromoaniline (2 eq) and diisopropylethylamine was refluxed in dimethylformamide. The resultant mixture was concentrated and partitioned between ethyl acetate and water. The organic layer was washed with brine and dried. Purification on silica gel gave (4-bromophenyl)(5-methoxybenzoxazol-2-yl)amine. MS: MH+=318

후처리

  1. concentrationThe resultant mixture was concentrated
  2. custompartitioned between ethyl acetate and water
  3. washThe organic layer was washed with brine
  4. customdried
  5. customPurification on silica gel

출처 및 근거

ORD 기록
ord-9bac4797f8dc4d1cae695a5979e23f2d
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728010B2

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