Hydrochloric Acid → HCID 178432390, 화합물

HRID 1348549노트

반응식

HRID 1348549 반응식
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[CH2:9][C:10](=O)[CH2:11]C(OCC)=O.[ClH:18].[NH2:19][C:20]1[NH:21][CH:22]=[CH:23][N:24]=1.[CH2:25]1CN2C(=NCCC2)C1.Cl.[OH2:35]>C(Cl)(Cl)Cl.CN(C)C=O>[OH:35][C:25]1[N:21]2[CH:22]=[CH:23][N:24]=[C:20]2[N:19]=[C:10]([CH3:11])[C:9]=1[C:3]1[C:4]([F:8])=[CH:5][CH:6]=[CH:7][C:2]=1[Cl:18]

참가 물질

8

반응물 5

HCID 313Hydrochloric AcidHCID 962Water2회HCID 763491,5-Diazabicyclo(4.3.0)non-5-eneHCID 122112381H-Imidazol-2-amine hydrochlorideHCID 63022492Ethyl (2-chloro-6-fluorophenyl)acetoacetate

생성물 1

HCID 178432390HCID 178432390, 화합물

시약·촉매·용매 2

HCID 6212Chloroform용매HCID 6228Dimethylformamide용매

반응 조건

온도
100 °C

실험 절차

A mixture of 1.29 g of ethyl (2-chloro-6-fluorophenyl)acetoacetate, 0.60 g of aminoimidazole hydrochloride, 1.24 g of 1,5-diazabicyclo[4.3.0]-5-nonene (DBN) and 5 ml of N,N-dimethylformamide was heated at 100° C. for 14 hours. The reaction mixture was allowed to cool, and chloroform and water were added thereto. To the separated water layer, conc. hydrochloric acid was added and the precipitate was filtered, which was followed to subject to silica gel chromatography to give 0.16 g of 5-hydroxy-6-(2-chloro-6-fluorophenyl)-7-methylimidazo[1,2-a]pyrimidine.

후처리

  1. temperatureto cool
  2. filtrationthe precipitate was filtered

출처 및 근거

ORD 기록
ord-7054545e715948659e3fcd2f805a7e49
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07211545B2

반응 노트

불러오는 중…