Methyl iodide → Benzoic Acid
반응식
NC1C=C(C=CC=1NC)OC1C=CN=C(C(NC)=O)C=1.N([C:24]1[CH:32]=[CH:31][C:27]([C:28]([OH:30])=[O:29])=[CH:26][CH:25]=1)=C=S.IC>CO>[C:28]([OH:30])(=[O:29])[C:27]1[CH:31]=[CH:32][CH:24]=[CH:25][CH:26]=1참가 물질
5
반응 조건
- 온도
- 60 °C
실험 절차
To {4-[3-amino-4-(methylamino)phenoxy](2-pyridyl)}-N-methylcarboxamide (1 eq) in methanol was added 4-isothiocyanatobenzoic acid (1 eq) and stirred at 60° C. for 3 h. To it was then added iodomethane (1 eq) and heated to 60° C. for 3 h. and concentrated the solvent and purified on silica gel to yield 4-({1-methyl-5-[2-(N-methylcarbamoyl)(4-pyridyloxy))]benzimidazol-2-yl}amino)benzoic acid. MS: MH+=417.
후처리
- concentrationconcentrated the solvent
- custompurified on silica gel
출처 및 근거
- ORD 기록
- ord-0db3fcedba7b4eb1b027317ca6693d87
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07728010B2
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