Chloroform → HCID 21094281, 화합물

HRID 1350073노트

반응식

HRID 1350073 반응식
[C:1]([CH:3]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[CH:9]=1)[C:4]([O:6][CH3:7])=[O:5])#[N:2].C(Cl)(Cl)[Cl:17]>CO.CCOCC.O=[Pt]=O>[ClH:17].[NH2:2][CH2:1][CH:3]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[CH:9]=1)[C:4]([O:6][CH3:7])=[O:5]

참가 물질

6

반응물 2

HCID 6212ChloroformHCID 69439208HCID 69439208, 화합물

생성물 1

HCID 21094281HCID 21094281, 화합물

시약·촉매·용매 3

HCID 345198Adams' catalyst촉매HCID 887Methanol용매HCID 3283Diethyl Ether용매

실험 절차

The compound obtained in Step A (34.32 g; 0.1672 mol) is dissolved in 150 ml of methanol. The solution is poured into an autoclave and then 50 ml of chloroform and platinium oxide (10% by weight) are added to the solution. The autoclave is placed under hydrogen pressure (60 bars) at ambient temperature and stirred magnetically for 24 hours. After removal of the catalyst by filtration, the solution is evaporated under reduced pressure. The oil obtained is taken up in ether. The precipitate formed is suction-filtered off and recrystallised from acetonitrile to yield the title product in the form of a white solid.

후처리

  1. additionThe solution is poured into an autoclave
  2. customat ambient temperature
  3. customAfter removal of the catalyst
  4. filtrationby filtration
  5. customthe solution is evaporated under reduced pressure
  6. customThe oil obtained
  7. customThe precipitate formed
  8. filtrationis suction-filtered off
  9. customrecrystallised from acetonitrile

출처 및 근거

ORD 기록
ord-5b8111009f8342d1b81da58aa1532995
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07214689B2

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