Lithium Hydroxide → 5-Isopropyl-2-(2-nitro-phenylamino)-benzonitrile

HRID 1350496노트

반응식

HRID 1350496 반응식
[NH2:1][C:2]1[CH:9]=[CH:8][C:7]([CH:10]([CH3:12])[CH3:11])=[CH:6][C:3]=1[C:4]#[N:5].F[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[N+:20]([O-:22])=[O:21].[OH-].[Li+]>CS(C)=O.O>[CH:10]([C:7]1[CH:8]=[CH:9][C:2]([NH:1][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[N+:20]([O-:22])=[O:21])=[C:3]([CH:6]=1)[C:4]#[N:5])([CH3:12])[CH3:11]

참가 물질

6

반응물 3

HCID 3939Lithium HydroxideHCID 738951-Fluoro-2-nitrobenzeneHCID 210934632-Amino-5-isopropylbenzonitrile

생성물 1

HCID 210935365-Isopropyl-2-(2-nitro-phenylamino)-benzonitrile

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 962Water용매

실험 절차

Combine 2-amino-5-isopropyl-benzonitrile (3.19 g, 20 mmol), 1-fluoro-2-nitro benzene (2.1 mL, 20 mmol) and lithium hydroxide (1.68 g, 40 mmol) in DMSO (40.0 mL) and heat at 55° C. for 19 hours. Cool to ambient temperature and dilute with water (200 mL). The title compound precipitates as 4.56 g of an orange solid: mp 91–96° C.; mass spectrum (ion spray) m/z=280 (M+1).

후처리

  1. customThe title compound precipitates as 4.56 g of an orange solid

출처 및 근거

ORD 기록
ord-c12a4745b3ba432e9a43576b7aae31ae
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07214673B2

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